Acute desensitization of GIRK current in rat atrial myocytes is related to K+current flow
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چکیده
منابع مشابه
Heartfelt crosstalk: desensitization of the GIRK current
caspase-3 (ref. 18). It has been shown that overexpression of Hsp70 does not preclude the activation of a caspase-3-like activity, but prevents the downstream morphological changes that are characteristic of dying cells. With regard to Hsp27, Pandey et al. have recently reported direct binding and inhibition of caspase-3 processing by this protein. However, the authors failed to detect an effec...
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Adenosine (Ado) is an important mediator of the endogenous defense against ischemia-induced injury in the heart. The action of Ado is mediated by activation of G protein-gated inwardly rectifying K(+) (GIRK) channels. In turn, GIRK channels are inhibited by reducing phosphatidylinositol 4,5-bisphosphate (PIP(2)) through Gq protein-coupled receptors (GqPCRs). We previously found that GIRK channe...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2004
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.072462